Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).
A non-haem iron and 2-oxoglutarate oxygenase, CarC catalyses the highly unusual epimerisation and desaturation of a (3S,5S)-carbapenam 2 to give a (5R)-carbapenem 1. All stereoisomers of 2 were synthesised and analysed as CarC substrates. The results imply that the (3S,5S)-carbapenam is an intermedi...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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