Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).
A non-haem iron and 2-oxoglutarate oxygenase, CarC catalyses the highly unusual epimerisation and desaturation of a (3S,5S)-carbapenam 2 to give a (5R)-carbapenem 1. All stereoisomers of 2 were synthesised and analysed as CarC substrates. The results imply that the (3S,5S)-carbapenam is an intermedi...
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Bibliographic Details
| Main Authors: |
Sleeman, M,
Smith, P,
Kellam, B,
Chhabra, SR,
Bycroft, B,
Schofield, C |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2004
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