Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury.

Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury.

BACKGROUND and AIMS: Liver ischemia/reperfusion (I/R) injury is a frequent cause of organ dysfunction. Loss of the oxygen sensor prolyl hydroxylase domain enzyme 1 (PHD1) causes tolerance of skeletal muscle to hypoxia. We assessed whether loss or short-term silencing of PHD1 could likewise induce h...

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Autors principals: Schneider, M, Van Geyte, K, Fraisl, P, Kiss, J, Aragonés, J, Mazzone, M, Mairbäurl, H, De Bock, K, Jeoung, N, Mollenhauer, M, Georgiadou, M, Bishop, T, Roncal, C, Sutherland, A, Jordan, B, Gallez, B, Weitz, J, Harris, R, Maxwell, P, Baes, M, Ratcliffe, P, Carmeliet, P
Format: Journal article
Idioma:English
Publicat: 2010

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