Optimising immunogenicity with viral vectors: mixing MVA and HAdV-5 expressing the mycobacterial antigen Ag85A in a single injection

The Bacillus Calmette - Guerin (BCG) vaccine provides a critical but limited defense against Mycobacterium tuberculosis (M.tb). More than 60 years after the widespread introduction of BCG, there is an urgent need for a better vaccine. A large body of pre-clinical research continues to support ongoin...

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Bibliographic Details
Main Authors: Betts, G, Poyntz, H, Stylianou, E, Reyes-Sandoval, A, Cottingham, M, Hill, A, McShane, H
Format: Journal article
Language:English
Published: Public Library of Science 2012