N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

R-loops are nucleic acid structures formed by an RNA:DNA hybrid and unpaired single-stranded DNA that represent a source of genomic instability in mammalian cells1,2,3,4. Here we show that N6-methyladenosine (m6A) modification, contributing to different aspects of messenger RNA metabolism5,6, is det...

Full description

Bibliographic Details
Main Authors: Abakir, A, Giles, TC, Cristini, A, Foster, JM, Dai, N, Starczak, M, Rubio-Roldan, A, Li, M, Eleftheriou, M, Crutchley, J, Flatt, L, Young, L, Gaffney, DJ, Denning, C, Dalhus, B, Emes, RD, Gackowski, D, Corrêa, IR, Garcia-Perez, JL, Klungland, A, Gromak, N, Ruzov, A
Format: Journal article
Language:English
Published: Springer Nature 2019

Similar Items