Identification and structure of the nerve growth factor binding site on TrkA.

Identification and structure of the nerve growth factor binding site on TrkA.

Nerve growth factor (NGF) is involved in the development and maintenance of the nervous system and has been implicated as a possible therapeutic target molecule in a number of neurodegenerative diseases, especially Alzheimer's disease. NGF binds with high affinity to the extracellular region of...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Robertson, A, Banfield, M, Allen, S, Dando, J, Mason, G, Tyler, S, Bennett, G, Brain, S, Clarke, A, Naylor, R, Wilcock, G, Brady, R, Dawbarn, D
التنسيق:	Journal article
اللغة:	English
منشور في:	2001

مواد مشابهة

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Postnatal changes in the expression of the trkA high-affinity NGF receptor in primary sensory neurons.
حسب: Bennett, D, وآخرون
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Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.
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Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain.
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Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling
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Role of NGF/TrkA signaling milieu in depressogenic induction of rat brain
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Secreted herpes simplex virus-2 glycoprotein G modifies NGF-TrkA signaling to attract free nerve endings to the site of infection.
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Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord.
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trkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat.
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