Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations

Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 c...

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Main Authors: Fehringer, G, Kraft, P, Pharoah, PD, Eeles, RA, Chatterjee, N, Schumacher, FR, Schildkraut, JM, Lindström, S, Brennan, P, Bickeböller, H, Houlston, RS, Landi, MT, Caporaso, N, Risch, A, Olama, A, Berndt, SI, Giovannucci, EL, Grönberg, H, Kote-Jarai, Z, Ma, J, Muir, K, Stampfer, MJ, Stevens, VL, Wiklund, F, Willett, WC, Goode, EL, Permuth, JB, Risch, HA, Reid, BM, Bezieau, S, Brenner, H, Chan, AT, Chang-Claude, J, Hudson, TJ, Kocarnik, JK, Newcomb, PA, Schoen, RE, Slattery, ML, White, E, Adank, MA, Ahsan, H, Aittomäki, K, Baglietto, L, Blomquist, C, Canzian, F, Czene, K, Dos-Santos-Silva, I, Eliassen, AH, Figueroa, JD, Flesch-Janys, D, Fletcher, O, Garcia-Closas, M, Gaudet, MM, Johnson, N, Hall, P, Hazra, A, Hein, R, Hofman, A, Hopper, JL, Irwanto, A, Johansson, M, Kaaks, R, Kibriya, MG, Lichtner, P, Liu, J, Lund, E, Makalic, E, Meindl, A, Müller-Myhsok, B, Muranen, TA, Nevanlinna, H, Peeters, PH, Peto, J, Prentice, RL, Rahman, N, Sanchez, MJ, Schmidt, DF, Schmutzler, RK, Southey, MC, Tamimi, R, Travis, RC, Turnbull, C, Uitterlinden, AG, Wang, Z, Whittemore, AS, Yang, XR, Zheng, W, Buchanan, DD, Casey, G, Conti, DV, Edlund, CK, Gallinger, S, Haile, RW, Jenkins, M, Le Marchand, L, Li, L, Lindor, NM, Schmit, SL, Thibodeau, SN, Woods, MO, Rafnar, T, Gudmundsson, J, Stacey, SN, Stefansson, K, Sulem, P, Chen, YA, Tyrer, JP, Christiani, DC, Wei, Y, Shen, H, Hu, Z, Shu, X-O, Shiraishi, K, Takahashi, A, Bossé, Y, Obeidat, M, Nickle, D, Timens, W, Freedman, ML, Li, Q, Seminara, D, Chanock, SJ, Gong, J, Peters, U, Gruber, SB, Amos, CI, Sellers, TA, Easton, DF, Hunter, DJ, Haiman, CA, Henderson, BE, Hung, RJ, Ovarian Cancer Association Consortium (Ocac), Practical Consortium, Hereditary Breast And Ovarian Cancer Research Group Netherlands (Hebon), Colorectal Transdisciplinary (Corect) Study, African American Breast Cancer Consortium (Aabc) And African Ancestry Prostate Cancer Consortium (Aapc)
Format: Journal article
Language:English
Published: American Association for Cancer Research 2016