Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of asso...

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Hlavní autoři: Lindgren, C, Heid, I, Randall, J, Lamina, C, Steinthorsdottir, V, Qi, L, Speliotes, E, Thorleifsson, G, Willer, C, Herrera, B, Jackson, A, Lim, N, Scheet, P, Soranzo, N, Amin, N, Aulchenko, Y, Chambers, J, Drong, A, Luan, J, Lyon, H, Rivadeneira, F, Sanna, S, Timpson, N, Zillikens, M, Zhao, J, Almgren, P, Bandinelli, S, Bennett, A, Bergman, R, Bonnycastle, L, Bumpstead, S, Chanock, S, Cherkas, L, Chines, P, Coin, L, Cooper, C, Crawford, G, Doering, A, Dominiczak, A, Doney, A, Ebrahim, S, Elliott, P, Erdos, MR, Estrada, K, Ferrucci, L, Fischer, G, Forouhi, N, Gieger, C, Grallert, H, Groves, C, Grundy, S, Guiducci, C, Hadley, D, Hamsten, A, Havulinna, A, Hofman, A, Holle, R, Holloway, J, Illig, T, Isomaa, B, Jacobs, L, Jameson, K, Jousilahti, P, Karpe, F, Kuusisto, J, Laitinen, J, Lathrop, G, Lawlor, D, Mangino, M, McArdle, W, Meitinger, T, Morken, M, Morris, A, Munroe, P, Narisu, N, Nordstrom, A, Nordstrom, P, Oostra, B, Palmer, C, Payne, F, Peden, J, Prokopenko, I, Renstrom, F, Ruokonen, A, Salomaa, V, Sandhu, MS, Scott, L, Scuteri, A, Silander, K, Song, K, Yuan, X, Stringham, H, Swift, A, Tuomi, T, Uda, M, Vollenweider, P, Waeber, G, Wallace, C, Walters, G, Weedon, M, Witteman, J, Zhang, C, Zhang, W, Caulfield, M, Collins, F, Smith, G, Day, I, Franks, P, Hattersley, A, Hu, F, Jarvelin, MR, Kong, A, Kooner, J, Laakso, M, Lakatta, E, Mooser, V, Peltonen, L, Samani, N, Spector, T, Strachan, D, Tanaka, T, Tuomilehto, J, Uitterlinden, A, van Duijn, C, Wareham, N, Waterworth, D, Boehnke, M, Deloukas, P, Groop, L, Hunter, D, Thorsteinsdottir, U, Schlessinger, D, Wichmann, H, Frayling, T, Abecasis, G, Hirschhorn, J, Loos, R, Stefansson, K, Mohlke, K, Barroso, I, McCarthy, M, Cons, W, Consortia, HWPROCARDIS, Consortium, GIANT, Davey Smith, G, Watkins For The Procardis Consortia, H, McCarthy For The Giant Consortium, MI
Médium: Journal article
Vydáno: Public Library of Science 2010