Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of asso...
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| Format: | Journal article |
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Public Library of Science
2010
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| _version_ | 1826274327603970048 |
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| author | Lindgren, C Heid, I Randall, J Lamina, C Steinthorsdottir, V Qi, L Speliotes, E Thorleifsson, G Willer, C Herrera, B Jackson, A Lim, N Scheet, P Soranzo, N Amin, N Aulchenko, Y Chambers, J Drong, A Luan, J Lyon, H Rivadeneira, F Sanna, S Timpson, N Zillikens, M Zhao, J Almgren, P Bandinelli, S Bennett, A Bergman, R Bonnycastle, L Bumpstead, S Chanock, S Cherkas, L Chines, P Coin, L Cooper, C Crawford, G Doering, A Dominiczak, A Doney, A Ebrahim, S Elliott, P Erdos, MR Estrada, K Ferrucci, L Fischer, G Forouhi, N Gieger, C Grallert, H Groves, C Grundy, S Guiducci, C Hadley, D Hamsten, A Havulinna, A Hofman, A Holle, R Holloway, J Illig, T Isomaa, B Jacobs, L Jameson, K Jousilahti, P Karpe, F Kuusisto, J Laitinen, J Lathrop, G Lawlor, D Mangino, M McArdle, W Meitinger, T Morken, M Morris, A Munroe, P Narisu, N Nordstrom, A Nordstrom, P Oostra, B Palmer, C Payne, F Peden, J Prokopenko, I Renstrom, F Ruokonen, A Salomaa, V Sandhu, MS Scott, L Scuteri, A Silander, K Song, K Yuan, X Stringham, H Swift, A Tuomi, T Uda, M Vollenweider, P Waeber, G Wallace, C Walters, G Weedon, M Witteman, J Zhang, C Zhang, W Caulfield, M Collins, F Smith, G Day, I Franks, P Hattersley, A Hu, F Jarvelin, MR Kong, A Kooner, J Laakso, M Lakatta, E Mooser, V Morris, A Peltonen, L Samani, N Spector, T Strachan, D Tanaka, T Tuomilehto, J Uitterlinden, A van Duijn, C Wareham, N Waterworth, D Boehnke, M Deloukas, P Groop, L Hunter, D Thorsteinsdottir, U Schlessinger, D Wichmann, H Frayling, T Abecasis, G Hirschhorn, J Loos, R Stefansson, K Mohlke, K Barroso, I McCarthy, M Cons, W Consortia, HWPROCARDIS Consortium, GIANT Davey Smith, G Watkins For The Procardis Consortia, H McCarthy For The Giant Consortium, MI |
| author_facet | Lindgren, C Heid, I Randall, J Lamina, C Steinthorsdottir, V Qi, L Speliotes, E Thorleifsson, G Willer, C Herrera, B Jackson, A Lim, N Scheet, P Soranzo, N Amin, N Aulchenko, Y Chambers, J Drong, A Luan, J Lyon, H Rivadeneira, F Sanna, S Timpson, N Zillikens, M Zhao, J Almgren, P Bandinelli, S Bennett, A Bergman, R Bonnycastle, L Bumpstead, S Chanock, S Cherkas, L Chines, P Coin, L Cooper, C Crawford, G Doering, A Dominiczak, A Doney, A Ebrahim, S Elliott, P Erdos, MR Estrada, K Ferrucci, L Fischer, G Forouhi, N Gieger, C Grallert, H Groves, C Grundy, S Guiducci, C Hadley, D Hamsten, A Havulinna, A Hofman, A Holle, R Holloway, J Illig, T Isomaa, B Jacobs, L Jameson, K Jousilahti, P Karpe, F Kuusisto, J Laitinen, J Lathrop, G Lawlor, D Mangino, M McArdle, W Meitinger, T Morken, M Morris, A Munroe, P Narisu, N Nordstrom, A Nordstrom, P Oostra, B Palmer, C Payne, F Peden, J Prokopenko, I Renstrom, F Ruokonen, A Salomaa, V Sandhu, MS Scott, L Scuteri, A Silander, K Song, K Yuan, X Stringham, H Swift, A Tuomi, T Uda, M Vollenweider, P Waeber, G Wallace, C Walters, G Weedon, M Witteman, J Zhang, C Zhang, W Caulfield, M Collins, F Smith, G Day, I Franks, P Hattersley, A Hu, F Jarvelin, MR Kong, A Kooner, J Laakso, M Lakatta, E Mooser, V Morris, A Peltonen, L Samani, N Spector, T Strachan, D Tanaka, T Tuomilehto, J Uitterlinden, A van Duijn, C Wareham, N Waterworth, D Boehnke, M Deloukas, P Groop, L Hunter, D Thorsteinsdottir, U Schlessinger, D Wichmann, H Frayling, T Abecasis, G Hirschhorn, J Loos, R Stefansson, K Mohlke, K Barroso, I McCarthy, M Cons, W Consortia, HWPROCARDIS Consortium, GIANT Davey Smith, G Watkins For The Procardis Consortia, H McCarthy For The Giant Consortium, MI |
| author_sort | Lindgren, C |
| collection | OXFORD |
| description | To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9×10−11) and MSRA (WC, P = 8.9×10−9). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6×10−8). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity. |
| first_indexed | 2024-03-06T22:42:03Z |
| format | Journal article |
| id | oxford-uuid:5bcf8e38-38f1-4c28-ab08-9a9f824bcbd2 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:42:03Z |
| publishDate | 2010 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:5bcf8e38-38f1-4c28-ab08-9a9f824bcbd22022-03-26T17:25:05ZGenome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat DistributionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5bcf8e38-38f1-4c28-ab08-9a9f824bcbd2Symplectic Elements at OxfordPublic Library of Science2010Lindgren, CHeid, IRandall, JLamina, CSteinthorsdottir, VQi, LSpeliotes, EThorleifsson, GWiller, CHerrera, BJackson, ALim, NScheet, PSoranzo, NAmin, NAulchenko, YChambers, JDrong, ALuan, JLyon, HRivadeneira, FSanna, STimpson, NZillikens, MZhao, JAlmgren, PBandinelli, SBennett, ABergman, RBonnycastle, LBumpstead, SChanock, SCherkas, LChines, PCoin, LCooper, CCrawford, GDoering, ADominiczak, ADoney, AEbrahim, SElliott, PErdos, MREstrada, KFerrucci, LFischer, GForouhi, NGieger, CGrallert, HGroves, CGrundy, SGuiducci, CHadley, DHamsten, AHavulinna, AHofman, AHolle, RHolloway, JIllig, TIsomaa, BJacobs, LJameson, KJousilahti, PKarpe, FKuusisto, JLaitinen, JLathrop, GLawlor, DMangino, MMcArdle, WMeitinger, TMorken, MMorris, AMunroe, PNarisu, NNordstrom, ANordstrom, POostra, BPalmer, CPayne, FPeden, JProkopenko, IRenstrom, FRuokonen, ASalomaa, VSandhu, MSScott, LScuteri, ASilander, KSong, KYuan, XStringham, HSwift, ATuomi, TUda, MVollenweider, PWaeber, GWallace, CWalters, GWeedon, MWitteman, JZhang, CZhang, WCaulfield, MCollins, FSmith, GDay, IFranks, PHattersley, AHu, FJarvelin, MRKong, AKooner, JLaakso, MLakatta, EMooser, VMorris, APeltonen, LSamani, NSpector, TStrachan, DTanaka, TTuomilehto, JUitterlinden, Avan Duijn, CWareham, NWaterworth, DBoehnke, MDeloukas, PGroop, LHunter, DThorsteinsdottir, USchlessinger, DWichmann, HFrayling, TAbecasis, GHirschhorn, JLoos, RStefansson, KMohlke, KBarroso, IMcCarthy, MCons, WConsortia, HWPROCARDISConsortium, GIANTDavey Smith, GWatkins For The Procardis Consortia, HMcCarthy For The Giant Consortium, MITo identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9×10−11) and MSRA (WC, P = 8.9×10−9). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6×10−8). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity. |
| spellingShingle | Lindgren, C Heid, I Randall, J Lamina, C Steinthorsdottir, V Qi, L Speliotes, E Thorleifsson, G Willer, C Herrera, B Jackson, A Lim, N Scheet, P Soranzo, N Amin, N Aulchenko, Y Chambers, J Drong, A Luan, J Lyon, H Rivadeneira, F Sanna, S Timpson, N Zillikens, M Zhao, J Almgren, P Bandinelli, S Bennett, A Bergman, R Bonnycastle, L Bumpstead, S Chanock, S Cherkas, L Chines, P Coin, L Cooper, C Crawford, G Doering, A Dominiczak, A Doney, A Ebrahim, S Elliott, P Erdos, MR Estrada, K Ferrucci, L Fischer, G Forouhi, N Gieger, C Grallert, H Groves, C Grundy, S Guiducci, C Hadley, D Hamsten, A Havulinna, A Hofman, A Holle, R Holloway, J Illig, T Isomaa, B Jacobs, L Jameson, K Jousilahti, P Karpe, F Kuusisto, J Laitinen, J Lathrop, G Lawlor, D Mangino, M McArdle, W Meitinger, T Morken, M Morris, A Munroe, P Narisu, N Nordstrom, A Nordstrom, P Oostra, B Palmer, C Payne, F Peden, J Prokopenko, I Renstrom, F Ruokonen, A Salomaa, V Sandhu, MS Scott, L Scuteri, A Silander, K Song, K Yuan, X Stringham, H Swift, A Tuomi, T Uda, M Vollenweider, P Waeber, G Wallace, C Walters, G Weedon, M Witteman, J Zhang, C Zhang, W Caulfield, M Collins, F Smith, G Day, I Franks, P Hattersley, A Hu, F Jarvelin, MR Kong, A Kooner, J Laakso, M Lakatta, E Mooser, V Morris, A Peltonen, L Samani, N Spector, T Strachan, D Tanaka, T Tuomilehto, J Uitterlinden, A van Duijn, C Wareham, N Waterworth, D Boehnke, M Deloukas, P Groop, L Hunter, D Thorsteinsdottir, U Schlessinger, D Wichmann, H Frayling, T Abecasis, G Hirschhorn, J Loos, R Stefansson, K Mohlke, K Barroso, I McCarthy, M Cons, W Consortia, HWPROCARDIS Consortium, GIANT Davey Smith, G Watkins For The Procardis Consortia, H McCarthy For The Giant Consortium, MI Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution |
| title | Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution |
| title_full | Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution |
| title_fullStr | Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution |
| title_full_unstemmed | Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution |
| title_short | Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution |
| title_sort | genome wide association scan meta analysis identifies three loci influencing adiposity and fat distribution |
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