Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

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To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of asso...

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Main Authors: Lindgren, C, Heid, I, Randall, J, Lamina, C, Steinthorsdottir, V, Qi, L, Speliotes, E, Thorleifsson, G, Willer, C, Herrera, B, Jackson, A, Lim, N, Scheet, P, Soranzo, N, Amin, N, Aulchenko, Y, Chambers, J, Drong, A, Luan, J, Lyon, H, Rivadeneira, F, Sanna, S, Timpson, N, Zillikens, M, Zhao, J, Almgren, P, Bandinelli, S, Bennett, A, Bergman, R, Bonnycastle, L, Bumpstead, S, Chanock, S, Cherkas, L, Chines, P, Coin, L, Cooper, C, Crawford, G, Doering, A, Dominiczak, A, Doney, A, Ebrahim, S, Elliott, P, Erdos, MR, Estrada, K, Ferrucci, L, Fischer, G, Forouhi, N, Gieger, C, Grallert, H, Groves, C, Grundy, S, Guiducci, C, Hadley, D, Hamsten, A, Havulinna, A, Hofman, A, Holle, R, Holloway, J, Illig, T, Isomaa, B, Jacobs, L, Jameson, K, Jousilahti, P, Karpe, F, Kuusisto, J, Laitinen, J, Lathrop, G, Lawlor, D, Mangino, M, McArdle, W, Meitinger, T, Morken, M, Morris, A, Munroe, P, Narisu, N, Nordstrom, A, Nordstrom, P, Oostra, B, Palmer, C, Payne, F, Peden, J, Prokopenko, I, Renstrom, F, Ruokonen, A, Salomaa, V, Sandhu, MS, Scott, L, Scuteri, A, Silander, K, Song, K, Yuan, X, Stringham, H, Swift, A, Tuomi, T, Uda, M, Vollenweider, P, Waeber, G, Wallace, C, Walters, G, Weedon, M, Witteman, J, Zhang, C, Zhang, W, Caulfield, M, Collins, F, Smith, G, Day, I, Franks, P, Hattersley, A, Hu, F, Jarvelin, MR, Kong, A, Kooner, J, Laakso, M, Lakatta, E, Mooser, V, Peltonen, L, Samani, N, Spector, T, Strachan, D, Tanaka, T, Tuomilehto, J, Uitterlinden, A, van Duijn, C, Wareham, N, Waterworth, D, Boehnke, M, Deloukas, P, Groop, L, Hunter, D, Thorsteinsdottir, U, Schlessinger, D, Wichmann, H, Frayling, T, Abecasis, G, Hirschhorn, J, Loos, R, Stefansson, K, Mohlke, K, Barroso, I, McCarthy, M, Cons, W, Consortia, HWPROCARDIS, Consortium, GIANT, Davey Smith, G, Watkins For The Procardis Consortia, H, McCarthy For The Giant Consortium, MI
Format: Journal article
Published: Public Library of Science 2010
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