Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barré syndrome mouse model

In Guillain-Barré syndrome (GBS), both axonal and demyelinating variants can be mediated by complement-fixing anti–GM1 ganglioside autoantibodies that target peripheral nerve axonal and Schwann cell (SC) membranes, respectively. Critically, the extent of axonal degeneration in both variants dictates...

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Autors principals: McGonigal, R, Campbell, CI, Barrie, JA, Yao, D, Cunningham, ME, Crawford, CL, Rinaldi, S, Rowan, EG, Willison, HJ
Format: Journal article
Idioma:English
Publicat: American Society for Clinical Investigation 2022