Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.

OBJECTIVE: Connective tissue growth factor (CTGF) is a cysteine-rich secreted matricellular protein involved in wound healing and tissue repair. Enhanced and prolonged expression of CTGF has been associated with tissue fibrosis in humans. However, questions remain as to whether CTGF expression alon...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Sonnylal, S, Shi-Wen, X, Leoni, P, Naff, K, Van Pelt, C, Nakamura, H, Leask, A, Abraham, D, Bou-Gharios, G, de Crombrugghe, B
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2010

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gan: Sonnylal, S, et al.
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gan: Shiwen, X, et al.
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gan: Sonnylal, S, et al.
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gan: Fragiadaki, M, et al.
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gan: Chan, A, et al.
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Myocardial tissue characterization and fibrosis by imaging
gan: Karamitsos, TD, et al.
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Bosentan alleviates the pro-fibrotic phenotype of lung scleroderma fibroblasts: Implications for treatment of scleroderma.
gan: Leask, A, et al.
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gan: Ito, A, et al.
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gan: Shiwen, X, et al.
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gan: Eastwood, M, et al.
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gan: Ikeda, T, et al.
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gan: Shi-wen, X, et al.
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gan: Renzoni, E, et al.
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gan: Jones, H, et al.
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Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
gan: Shi-Wen, X, et al.
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gan: Denton, C, et al.
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Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
gan: Xu, S, et al.
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T-cell-dependent fibrosis in the mdx dystrophic mouse.
gan: Morrison, J, et al.
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Effects of T-lymphocyte depletion on muscle fibrosis in the mdx mouse.
gan: Morrison, J, et al.
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gan: Fang, S, et al.
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PGE2 in fibrosis and cancer: Insights into fibroblast activation
gan: Elwakeel, Eiman, et al.
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NON-INVASIVE IMAGING FOR THE ASSESSMENT OF DERMAL FIBROSIS
gan: Jones, H, et al.
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Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction.
gan: Alexakis, C, et al.
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Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.
gan: Shi-Wen, X, et al.
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Mapping of the fibroblast growth factors in human white adipose tissue.
gan: Mejhert, N, et al.
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Fibroblast heterogeneity: keystone of tissue homeostasis and pathology in inflammation and ageing
gan: Gauthier, V, et al.
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Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).
gan: Denton, C, et al.
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Controlling the Fibroblastic Differentiation of Mesenchymal Stem Cells Via the Combination of Fibrous Scaffolds and Connective Tissue Growth Factor
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Response of human lung fibroblast cells to stimulation by endothelin-1: Involvement of ras/MEK/ERK and PI3 kinase
gan: Shiwen, X, et al.
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gan: Wordsworth, P, et al.
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Human bone tissue formation in diffusion chamber culture in vivo by bone-derived cells and marrow stromal fibroblastic cells.
gan: Gundle, R, et al.
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Generation of an inducible cartilage-specific deleter using human aggrecan enhancer/promoter that is trackable in vivo using luciferase
gan: Lo Cascio, L, et al.
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Col1a2 enhancer regulates collagen activity during development and in adult tissue repair.
gan: Ponticos, M, et al.
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CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
gan: Shi-wen, X, et al.
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