Multi-center evaluation of the fully automated PCR-based Idylla™ KRAS mutation assay for rapid KRAS mutation status determination on formalin-fixed paraffin-embedded tissue of human colorectal cancer

Multi-center evaluation of the fully automated PCR-based Idylla™ KRAS mutation assay for rapid KRAS mutation status determination on formalin-fixed paraffin-embedded tissue of human colorectal cancer

<p>Since the advent of monoclonal antibodies against epidermal growth factor receptor (EGFR) in colorectal cancer therapy, the determination of RAS mutational status is needed for therapeutic decision-making. Most prevalent in colorectal cancer are <em>KRAS</em> exon 2 mutations (4...

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Bibliographic Details
Main Authors: Solassol, J, Vendrell, J, Märkl, B, Haas, C, Bellosillo, B, Montagut, C, Smith, M, O'Sullivan, B, D'Haene, N, Le Mercier, M, Grauslund, M, Melchior, L, Burt, E, Cotter, F, Stieber, D, Schmitt, F, Motta, V, Lauricella, C, Colling, R, Soilleux, E, Fassan, M, Mescoli, C, Collin, C, Pagès, J, Sillekens, P
Format: Journal article
Language:English
Published: Public Library of Science 2016

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