Entorhinal‐based path integration selectively predicts midlife risk of Alzheimer's disease
INTRODUCTION: Entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration (PI)–based spatial behaviors, we predicted that PI impairment would represent th...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley Open Access
2024
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| _version_ | 1826313062998605824 |
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| author | Newton, C Pope, M Rua, C Henson, R Ji, Z Burgess, N Rodgers, CT Stangl, M Dounavi, M Castegnaro, A Koychev, I Malhotra, P Wolbers, T Ritchie, K Ritchie, CW O'Brien, J Su, L Chan, D |
| author_facet | Newton, C Pope, M Rua, C Henson, R Ji, Z Burgess, N Rodgers, CT Stangl, M Dounavi, M Castegnaro, A Koychev, I Malhotra, P Wolbers, T Ritchie, K Ritchie, CW O'Brien, J Su, L Chan, D |
| author_sort | Newton, C |
| collection | OXFORD |
| description | INTRODUCTION: Entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration (PI)–based spatial behaviors, we predicted that PI impairment would represent the first behavioral change in adults at risk of AD. METHODS: We compared immersive virtual reality (VR) PI ability to other cognitive domains in 100 asymptomatic midlife adults stratified by hereditary and physiological AD risk factors. In some participants, behavioral data were compared to 7T magnetic resonance imaging (MRI) measures of brain structure and function. RESULTS: Midlife PI impairments predicted both hereditary and physiological AD risk, with no corresponding multi‐risk impairment in episodic memory or other spatial behaviors. Impairments associated with altered functional MRI signal in the posterior‐medial EC. DISCUSSION: Altered PI may represent the transition point from at‐risk state to disease manifestation in AD, prior to impairment in other cognitive domains. |
| first_indexed | 2024-09-25T04:05:06Z |
| format | Journal article |
| id | oxford-uuid:5c664da6-014b-4f99-8c93-0dbd0811291a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:05:06Z |
| publishDate | 2024 |
| publisher | Wiley Open Access |
| record_format | dspace |
| spelling | oxford-uuid:5c664da6-014b-4f99-8c93-0dbd0811291a2024-05-30T09:17:14ZEntorhinal‐based path integration selectively predicts midlife risk of Alzheimer's diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5c664da6-014b-4f99-8c93-0dbd0811291aEnglishJisc Publications RouterWiley Open Access2024Newton, CPope, MRua, CHenson, RJi, ZBurgess, NRodgers, CTStangl, MDounavi, MCastegnaro, AKoychev, IMalhotra, PWolbers, TRitchie, KRitchie, CWO'Brien, JSu, LChan, DINTRODUCTION: Entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration (PI)–based spatial behaviors, we predicted that PI impairment would represent the first behavioral change in adults at risk of AD. METHODS: We compared immersive virtual reality (VR) PI ability to other cognitive domains in 100 asymptomatic midlife adults stratified by hereditary and physiological AD risk factors. In some participants, behavioral data were compared to 7T magnetic resonance imaging (MRI) measures of brain structure and function. RESULTS: Midlife PI impairments predicted both hereditary and physiological AD risk, with no corresponding multi‐risk impairment in episodic memory or other spatial behaviors. Impairments associated with altered functional MRI signal in the posterior‐medial EC. DISCUSSION: Altered PI may represent the transition point from at‐risk state to disease manifestation in AD, prior to impairment in other cognitive domains. |
| spellingShingle | Newton, C Pope, M Rua, C Henson, R Ji, Z Burgess, N Rodgers, CT Stangl, M Dounavi, M Castegnaro, A Koychev, I Malhotra, P Wolbers, T Ritchie, K Ritchie, CW O'Brien, J Su, L Chan, D Entorhinal‐based path integration selectively predicts midlife risk of Alzheimer's disease |
| title | Entorhinal‐based path integration selectively predicts midlife risk of Alzheimer's disease |
| title_full | Entorhinal‐based path integration selectively predicts midlife risk of Alzheimer's disease |
| title_fullStr | Entorhinal‐based path integration selectively predicts midlife risk of Alzheimer's disease |
| title_full_unstemmed | Entorhinal‐based path integration selectively predicts midlife risk of Alzheimer's disease |
| title_short | Entorhinal‐based path integration selectively predicts midlife risk of Alzheimer's disease |
| title_sort | entorhinal based path integration selectively predicts midlife risk of alzheimer s disease |
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