Use of antisense-mediated exon skipping to generate dystrophin in muscles of the mdx dystrophic mouse

Eitemau Tebyg

• Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse.
  gan: Lu, Q, et al.
  Cyhoeddwyd: (2003)
• Bodywide skipping of exons 45-55 in dystrophic mdx52 mice by systemic antisense delivery.
  gan: Aoki, Y, et al.
  Cyhoeddwyd: (2012)
• T-cell-dependent fibrosis in the mdx dystrophic mouse.
  gan: Morrison, J, et al.
  Cyhoeddwyd: (2000)
• Good news for the mdx mouse community: Improved dystrophin restoration after skipping mouse dystrophin exon 23
  gan: Annemieke Aartsma-Rus
  Cyhoeddwyd: (2022-12-01)
• In-frame dystrophin following exon 51-skipping improves muscle pathology and function in the exon 52-deficient mdx mouse.
  gan: Aoki, Y, et al.
  Cyhoeddwyd: (2010)