Characterisation of the HIV-1 reservoir and the potential for viral eradication

Characterisation of the HIV-1 reservoir and the potential for viral eradication

<p>The HIV-1 reservoir is the major barrier to eradication and cure of HIV-1 infection. The aim of this thesis was to characterise the HIV-1 reservoir in PHI and to investigate two potential reservoir clearance strategies.</p> <p>Sensitive Q-PCR assays that quantify HIV-1 DNA reser...

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Manylion Llyfryddiaeth
Prif Awduron:	Williams, J, James Williams
Awduron Eraill:	Frater, J
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2014
Pynciau:	Infectious diseases HIV/AIDS Viruses Immunology

Eitemau Tebyg

Natural and therapy-induced immune control of HIV-1
gan: Yager, N
Cyhoeddwyd: (2011)

Identification of immunological targets for HIV-1 vaccine and cure strategies
gan: Hancock, G
Cyhoeddwyd: (2014)

The impact of host and therapy mediated selection on HIV-1 evolution
gan: Huang, K
Cyhoeddwyd: (2010)

Naive infection predicts reservoir diversity and is a formidable hurdle to HIV eradication
gan: Marilia R. Pinzone, et al.
Cyhoeddwyd: (2021-08-01)

HLA-B51 associated HIV-1 viral control
gan: Peng, Y
Cyhoeddwyd: (2013)

HIV-1 transmission between T cells and macrophages: consequences for viral pathogenesis.
gan: Baxter, A
Cyhoeddwyd: (2013)

Characterisation of T cells induced by candidate conserved region HIV-1 vaccines in healthy HIV-1/2 negative volunteers
gan: Ahmed, T, et al.
Cyhoeddwyd: (2014)

Immunodominant CD8+ T cell responses to HIV-1 infection - 'The good and the bad'
gan: Culshaw, A
Cyhoeddwyd: (2011)

A study of the phenotype and function of HLA-C restricted CD8 T cells in HIV-1 infection
gan: Corrah, TW
Cyhoeddwyd: (2011)

Architecture of the HIV-1 glycan shield
gan: Pritchard, L
Cyhoeddwyd: (2014)

Imaging of HIV-1 spread from T cells and Macrophages to Astrocytes
gan: Do, T
Cyhoeddwyd: (2014)

The impact of HIV-1 disease and its treatment on mycobacterium tuberculosis-specific immunity
gan: Murray, L
Cyhoeddwyd: (2014)

The design and development of an HIV-1 vaccine to elicit a broadly neutralising antibody response
gan: Wan, L, et al.
Cyhoeddwyd: (2012)

Population-specific HLA impact in immune control of HIV in Mexico and non-Mexican HIV infected cohorts
gan: Juarez Molina, CI
Cyhoeddwyd: (2014)

T-cell receptor (TCR) usage in HIV-2 infection
gan: Moysi, E
Cyhoeddwyd: (2012)

Characterisation of the immune response to PARV4
gan: Simmons, RA
Cyhoeddwyd: (2011)

The role of Nef protein in the pathogenesis of HIV infection
gan: Rajapaksa, U
Cyhoeddwyd: (2013)

HIV-specific interleukin-10 responses and immune modulation
gan: Clutton, G
Cyhoeddwyd: (2012)

The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory CD4+ T cells
gan: Gabriel Duette, et al.
Cyhoeddwyd: (2022-04-01)

T cell responses in Kenyan infants: impact on HIV-1 evolution during infection and an assessment of vaccine-induced memory responses in HIV-exposed uninfected infants
gan: Garcia Knight, M
Cyhoeddwyd: (2014)

Killer immunoglobulin-like receptor polymorphism in a Chinese HIV-1 infection cohort
gan: Wang, L
Cyhoeddwyd: (2014)

Distinct mucosal and systemic immunological characteristics in transgender women potentially relating to HIV acquisition
gan: Alexandra Schuetz, et al.
Cyhoeddwyd: (2023-08-01)

Antibody-dependent cellular cytotoxicity responses and susceptibility influence HIV-1 mother-to-child transmission
gan: Allison S. Thomas, et al.
Cyhoeddwyd: (2022-05-01)

Definition of the early HIV-1 signalosome in dendritic cells
gan: Khatamzas, E
Cyhoeddwyd: (2013)

High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo
gan: Simmons, R, et al.
Cyhoeddwyd: (2011)

Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection
gan: Julie L. Mitchell, et al.
Cyhoeddwyd: (2022-01-01)

Gut-derived bacterial toxins impair memory CD4+ T cell mitochondrial function in HIV-1 infection
gan: Brian Ferrari, et al.
Cyhoeddwyd: (2022-05-01)

Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype
gan: Vinicius Vieira, et al.
Cyhoeddwyd: (2023-02-01)

Higher circulating intermediate monocytes are associated with cognitive function in women with HIV
gan: Rebecca T. Veenhuis, et al.
Cyhoeddwyd: (2021-06-01)

Assessment of HIV-1 integration in tissues and subsets across infection stages
gan: Vincent H. Wu, et al.
Cyhoeddwyd: (2020-12-01)

TCF-1 regulates HIV-specific CD8+ T cell expansion capacity
gan: Rachel L. Rutishauser, et al.
Cyhoeddwyd: (2021-02-01)

Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy
gan: Justin Harper, et al.
Cyhoeddwyd: (2022-04-01)

Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo
gan: Shane D. Falcinelli, et al.
Cyhoeddwyd: (2022-04-01)

Structural and biophysical studies of HIV Rev and HBV e-antigen
gan: DiMattia, M
Cyhoeddwyd: (2012)

IL-15 enhances HIV-1 infection by promoting survival and proliferation of CCR5+CD4+ T cells
gan: Yuhao Li, et al.
Cyhoeddwyd: (2023-04-01)

The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection
gan: Liseth Carmona-Pérez, et al.
Cyhoeddwyd: (2023-07-01)

A functional and structural study of HLA-B*2705 restricted CTL responses associated with delayed HIV-1 disease progression
gan: Pymm, PG
Cyhoeddwyd: (2012)

Distinct patterns of natural selection in the reverse transcriptase gene of HIV-1 in the presence and absence of antiretroviral therapy
gan: Leal, É, et al.
Cyhoeddwyd: (2004)

Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells
gan: Wouter A. van der Heijden, et al.
Cyhoeddwyd: (2021-04-01)

The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells
gan: Dennis C. Copertino Jr., et al.
Cyhoeddwyd: (2023-09-01)