Synthesis and C-alkylation of hindered aldehyde enamines.

A new reactivity mode of hindered lithium amides with terminal epoxides is described whereby aldehyde enamines are produced via a previously unrecognized reaction pathway. Some of these aldehyde enamines display unprecedented C-alkylation reactivity toward unactivated primary and secondary alkyl hal...

Full description

Bibliographic Details
Main Authors: Hodgson, D, Bray, C, Kindon, N, Reynolds, N, Coote, S, Um, J, Houk, K
Format: Journal article
Language:English
Published: 2009