Synthesis and C-alkylation of hindered aldehyde enamines.
A new reactivity mode of hindered lithium amides with terminal epoxides is described whereby aldehyde enamines are produced via a previously unrecognized reaction pathway. Some of these aldehyde enamines display unprecedented C-alkylation reactivity toward unactivated primary and secondary alkyl hal...
Main Authors: | Hodgson, D, Bray, C, Kindon, N, Reynolds, N, Coote, S, Um, J, Houk, K |
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Format: | Journal article |
Language: | English |
Published: |
2009
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