Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes

Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes

In severe falciparum malaria cytoadherence of parasitised red blood cells (PRBCs) to vascular endothelium (causing sequestration) and to uninfected red cells (causing rosette formation) contribute to microcirculatory flow obstruction in vital organs. Heparin can reverse the underlying ligand-recepto...

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Bibliographic Details
Main Authors: Saiwaew, S, Sritabal, J, Piaraksa, N, Keayarsa, S, Ruengweerayut, R, Utaisin, C, Sila, P, Niramis, R, Udomsangpetch, R, Charunwatthana, P, Pongponratn, E, Pukrittayakamee, S, Leitgeb, A, Wahlgren, M, Lee, S, Day, N, White, N, Dondorp, A, Chotivanich, K
Other Authors: Craig, A
Format: Journal article
Language:English
Published: Public Library of Science 2017
Subjects:
Blood groups
Plasmodium
Malarial parasites
Malaria
Parasitic diseases
Red blood cells
Endothelial cells
Heparin

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