SYNTHESIS FROM A HEPTONOLACTONE AND EFFECT ON GLYCOSIDASES OF (1S,2R,6R,7S)-1,2,6,7-TETRAHYDROXYPYRROLIZIDINE

A five step synthesis of the pseudo C2 symmetric (1S,2R,6R,7S)-1,2,6,7-tetrahydroxypyrrolizidine from 2,3:5,6-di-O-isopropylidene-D-glycero-D-talo-heptono-1,4-lactone is reported. The effects of structure of some polyhydroxylated pyrrolizidines and pyrrolidines on inhibition of mannosidases are comp...

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Autori principali: Fairbanks, A, Fleet, G, Jones, A, Bruce, I, Aldaher, S, Dibello, I, Winchester, B
Natura: Journal article
Lingua:English
Pubblicazione: 1991