Glucopyranose spirohydantoins: Specific inhibitors of glycogen phosphorylase

A short synthesis of the spirohydantoin of glucopyranose 1β [a potent and specific inhibitor of glycogen phosphorylase], together with its inactive anomer 1α, from a readily available heptonolactone is described; this is the first synthesis of a spirohydantoin of a pyranose in which the pyranose rin...

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Bibliographic Details
Main Authors: delaFuente, C, Krulle, T, Watson, K, Gregoriou, M, Johnson, L, Tsitsanou, K, Zographos, SE, Oikonomakos, N, Fleet, G
Format: Journal article
Language:English
Published: 1997