Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

How lipopolysaccharide (LPS) signals through toll-like receptors (TLRs) to induce nuclear factor (NF)-kappa B inflammatory cytokines in sepsis remains unclear. Major candidates for that process are myeloid differentiation protein 88 (MyD88) and MyD88 adaptor-like/TIR domain-containing adaptor protei...

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Bibliographic Details
Main Authors:	Andreakos, E, Sacre, S, Smith, C, Lundberg, A, Kiriakidis, S, Stonehouse, T, Monaco, C, Feldmann, M, Foxwell, B
Format:	Journal article
Language:	English
Published:	2004

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