Prospects for the computational humanization of antibodies and nanobodies

To be viable therapeutics, antibodies must be tolerated by the human immune system. Rational approaches to reduce the risk of unwanted immunogenicity involve maximizing the ‘humanness’ of the candidate drug. However, despite the emergence of new discovery technologies, many of which start from entir...

Full description

Bibliographic Details
Main Authors: Gordon, GL, Raybould, MIJ, Wong, A, Deane, CM
Format: Journal article
Language:English
Published: Frontiers Media 2024