Prospects for the computational humanization of antibodies and nanobodies
To be viable therapeutics, antibodies must be tolerated by the human immune system. Rational approaches to reduce the risk of unwanted immunogenicity involve maximizing the ‘humanness’ of the candidate drug. However, despite the emergence of new discovery technologies, many of which start from entir...
Main Authors: | Gordon, GL, Raybould, MIJ, Wong, A, Deane, CM |
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Format: | Journal article |
Language: | English |
Published: |
Frontiers Media
2024
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