Mathematical modelling and transcriptional characterisation of intratumoral regulatory T cell sub-populations

Mathematical modelling and transcriptional characterisation of intratumoral regulatory T cell sub-populations

<p>Regulatory T cells (Tregs) suppress harmful immune responses and help prevent autoimmune reactions. However, high densities of Tregs accumulate in solid tumours and contribute to the suppression of anti-tumor responses. The targeting of intratumoral Tregs via antibody-mediated blockade/depl...

Полное описание

Библиографические подробности
Главный автор:	Muzhingi, I
Другие авторы:	Coles, M
Формат:	Диссертация
Язык:	English
Опубликовано:	2023
Предметы:	Computational Biology Computational Immunology Immuno-oncology

Схожие документы

Characterising CD8+ T cell transcriptomic and clonal consequences of immune checkpoint blockade for the treatment of cancer
по: Watson, RA
Опубликовано: (2023)

Patient-Specific Cell Communication Networks Associate With Disease Progression in Cancer
по: David L. Gibbs, и др.
Опубликовано: (2021-08-01)

In silico simulation of a clinical trial with anti-CTLA-4 and anti-PD-L1 immunotherapies in metastatic breast cancer using a systems pharmacology model
по: Hanwen Wang, и др.
Опубликовано: (2019-05-01)

Neoadjuvant chemotherapy drives intratumoral T cells toward a proinflammatory profile in pancreatic cancer
по: Max Heiduk, и др.
Опубликовано: (2022-11-01)

ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data
по: James W Opzoomer, и др.
Опубликовано: (2021-04-01)

Editorial: Systems Biology Methods in Computational Immuno-Oncology
по: Andrei S. Rodin, и др.
Опубликовано: (2022-04-01)

Editorial: Tumor microenvironment complexity and its therapeutic implications
по: Denner Santos dos Anjos, и др.
Опубликовано: (2025-01-01)

A study of regulatory T cells in allogeneic haematopoietic stem cell transplantation
по: Danby, RD
Опубликовано: (2012)

Immuno-oncology in head and neck squamous cell carcinoma - a narrative review
по: A.T. da Silva, и др.
Опубликовано: (2023-03-01)

Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response
по: Shuming Zhang, и др.
Опубликовано: (2021-10-01)

Deep phenotyping of surface stimulatory and inhibitory co-receptors on cancer-resident T and NK cells reveals cell subsets within the tumor-reactive CTL population that are uniquely defined by NKG2A expression
по: James Hair, и др.
Опубликовано: (2022-03-01)

Immune regulatory networks in inflammation-driven cancer
по: Franchini, F
Опубликовано: (2017)

A cell-engineered system to assess tumor cell sensitivity to CD8+ T cell-mediated cytotoxicity
по: Nadine Nelson, и др.
Опубликовано: (2019-08-01)

Get to know your neighbors with a SNAQ™: A framework for single cell spatial neighborhood analysis in immunohistochemical images
по: Aryeh Silver, и др.
Опубликовано: (2024-12-01)

A bispecific anti-PD-1 and PD-L1 antibody induces PD-1 cleavage and provides enhanced anti-tumor activity
по: Diana I. Albu, и др.
Опубликовано: (2024-12-01)

Phenotypic modelling of the polyfunctional T cell response
по: Trendel, N
Опубликовано: (2018)

Immuno-oncological treatment of Non-Small-Cell Lung Cancer (NSCLC) in advanced stage with Nivolumab
по: Fabio Venturella, и др.
Опубликовано: (2023-03-01)

Delineating the nexus between gut-intratumoral microbiome and osteo-immune system in bone metastases
по: Shreya Kapoor, и др.
Опубликовано: (2024-12-01)

Characterisation of macrophage infiltration into solid tumours via image analysis and computational modelling
по: Bull, J
Опубликовано: (2018)

Characterising the role of circulating immune cells in brain metastasis
по: Balathasan, L
Опубликовано: (2012)

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity
по: Liqing Wang, и др.
Опубликовано: (2016-11-01)

Osteoimmuno-Oncology: Therapeutic Opportunities for Targeting Immune Cells in Bone Metastasis
по: Tiina E. Kähkönen, и др.
Опубликовано: (2021-06-01)

Future prospects for breast cancer immunotherapy
по: V. F. Semiglazov, и др.
Опубликовано: (2018-11-01)

Conducting a Virtual Clinical Trial in HER2-Negative Breast Cancer Using a Quantitative Systems Pharmacology Model With an Epigenetic Modulator and Immune Checkpoint Inhibitors
по: Hanwen Wang, и др.
Опубликовано: (2020-02-01)

Next generation immuno-oncology tumor profiling using a rapid, non-invasive, computational biophysics biomarker in early-stage breast cancer
по: Daniel Cook, и др.
Опубликовано: (2023-04-01)

IL-18–secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models
по: Janneke E. Jaspers, и др.
Опубликовано: (2023-05-01)

High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer
по: Shouyu Ke, и др.
Опубликовано: (2022-12-01)

A multiplexed assay for quantifying immunomodulatory proteins supports correlative studies in immunotherapy clinical trials
по: Jeffrey R. Whiteaker, и др.
Опубликовано: (2023-05-01)

Lymphopenia-induced lymphoproliferation drives activation of naive T cells and expansion of regulatory populations
по: Eldershaw S, и др.
Опубликовано: (2021-03-01)

Autotaxin suppresses cytotoxic T cells via LPAR5 to promote anti–PD-1 resistance in non–small cell lung cancer
по: Jessica M. Konen, и др.
Опубликовано: (2023-09-01)

Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma
по: Benedetta Apollonio, и др.
Опубликовано: (2023-07-01)

CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy
по: Miriam Y. Kim, и др.
Опубликовано: (2021-08-01)

B cell receptor isotypes differentially associate with cell signaling, kinetics, and outcome in chronic lymphocytic leukemia
по: Andrea N. Mazzarello, и др.
Опубликовано: (2022-01-01)

Tumor cells fail to present MHC-II–restricted epitopes derived from oncogenes to CD4+ T cells
по: Spencer E. Brightman, и др.
Опубликовано: (2023-01-01)

Investigating small non-coding RNA regulating the hallmarks of cancer
по: Dhawan, A
Опубликовано: (2018)

Decitabine priming increases anti–PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T cell expansion in tumor models
по: Xiang Li, и др.
Опубликовано: (2023-04-01)

Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses
по: Gabrielle Romain, и др.
Опубликовано: (2022-09-01)

The role of LARP1 in communication between ovarian tumours and their immune microenvironment
по: Gross, F
Опубликовано: (2022)

A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation
по: Alessandro Mega, и др.
Опубликовано: (2023-12-01)

Collectin-11 promotes cancer cell proliferation and tumor growth
по: Jia-Xing Wang, и др.
Опубликовано: (2023-03-01)