Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

The cytokine interleukin 6 (IL6) is a key mediator of inflammation that contributes to skeletal muscle pathophysiology. IL6 activates target cells by two main mechanisms, the classical and trans-signalling pathways. While classical signalling is associated with the anti-inflammatory activities of th...

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Bibliographic Details
Main Authors: Conceiçao, M, Forcina, L, Wiklander, OPB, Gupta, D, Nordin, JZ, Vrellaku, B, McClorey, G, Mäger, I, Gӧrgens, A, Lundin, P, Musarò, A, Wood, MJA, El Andaloussi, S, Roberts, TC
Format: Journal article
Language:English
Published: Elsevier 2020