Steered molecular dynamics simulations predict conformational stability of glutamate receptors.

Steered molecular dynamics simulations predict conformational stability of glutamate receptors.

The stability of protein-protein interfaces can be essential for protein function. For ionotropic glutamate receptors, a family of ligand-gated ion channels vital for normal function of the central nervous system, such an interface exists between the extracellular ligand binding...

Bibliografske podrobnosti
Main Authors:	Musgaard, M, Biggin, P
Format:	Journal article
Jezik:	English
Izdano:	American Chemical Society 2016

Podobne knjige/članki

Simulation studies of glutamate receptors.
od: Biggin, P, et al.
Izdano: (2003)

Comparative molecular dynamics simulations: Glutamate receptors and periplasmic binding proteins
od: Sansom, M, et al.
Izdano: (2004)

Conformational dynamics of glutamate receptors: MD simulations of the ligand-binding domains of GluR2 and GluR0
od: Arinaminpathy, Y, et al.
Izdano: (2004)

Ionontropic Glutamate Receptors: Insight into the Mechanism of Desensitization and Deactivation using Molecular Dynamics Simulations
od: Amara, N, et al.
Izdano: (2012)

Molecular dynamics simulations of the ligand-binding domain of the ionotropic glutamate receptor GluR2.
od: Arinaminpathy, Y, et al.
Izdano: (2002)

A prokaryotic glutamate receptor: homology modelling and molecular dynamics simulations of GluR0.
od: Arinaminpathy, Y, et al.
Izdano: (2003)

Glutamate receptors: desensitizing dimers.
od: Biggin, P
Izdano: (2002)

Binding site flexibility: Molecular simulation of partial and full agonists within a glutamate receptor
od: Arinaminpathy, Y, et al.
Izdano: (2006)

Binding site flexibility: molecular simulation of partial and full agonists within a glutamate receptor.
od: Arinaminpathy, Y, et al.
Izdano: (2006)

Insights into channel dysfunction from modelling and molecular dynamics simulations
od: Musgaard, M, et al.
Izdano: (2017)

Computational studies of receptors
od: Musgaard, M, et al.
Izdano: (2016)

Homology modelling and molecular dynamics simulations of a prokaryotic glutamate receptor: GluR0
od: Arinaminpathy, Y, et al.
Izdano: (2002)

A refined open state of the glycine receptor obtained via molecular dynamics simulations
od: Dämgen, M, et al.
Izdano: (2019)

Molecular dynamics simulations of the ligand-binding domain of an N-methyl-D-aspartate receptor.
od: Kaye, S, et al.
Izdano: (2006)

A Refined Open State of the Glycine Receptor Obtained via Molecular Dynamics Simulations
od: Dämgen, MA, et al.
Izdano: (2019)

A comparative analysis of the role of water in the binding pockets of ionotropic glutamate receptors.
od: Vijayan, R, et al.
Izdano: (2010)

Quantifying water-mediated protein-ligand interactions in a glutamate receptor: a DFT study
od: Sahai, M, et al.
Izdano: (2011)

Quantifying water-mediated protein-ligand interactions in a glutamate receptor: a DFT study.
od: Sahai, M, et al.
Izdano: (2011)

Molecular dynamics simulations of membrane proteins.
od: Biggin, P, et al.
Izdano: (2008)

Rigid body essential X-ray crystallography: distinguishing the bend and twist of glutamate receptor ligand binding domains.
od: Bjerrum, E, et al.
Izdano: (2008)

Functional validation of Heteromeric Kainate receptor models
od: Paramo, T, et al.
Izdano: (2017)

Direct versatile route to conformationally constrained glutamate analogues
od: Dyer, J, et al.
Izdano: (1998)

Atomistic Simulations Explain Mutational Effects on Ion Modulation and Kainate Receptor Activity
od: Musgaard, M, et al.
Izdano: (2013)

Metabotropic glutamate receptor agonists for schizophrenia.
od: Harrison, P
Izdano: (2008)

Glutamate receptors and transporters in the hippocampus in schizophrenia.
od: Harrison, P, et al.
Izdano: (2003)

Distinct structural pathways coordinate the activiation of AMPA receptor-auxiliary subunit complexes
od: Dawe, G, et al.
Izdano: (2016)

Thermal unfolding and conformational stability of the recombinant domain II of glutamate dehydrogenase from the hyperthermophile Thermotoga maritima.
od: Consalvi, V, et al.
Izdano: (2000)

Molecular basis for redox control by the human cystine/glutamate antiporter system xc−
od: Parker, J, et al.
Izdano: (2021)

Molecular Dynamic Simulations Reveal that Water-Soluble QTY-Variants of Glutamate Transporters EAA1, EAA2 and EAA3 Retain the Conformational Characteristics of Native Transporters
od: Karagöl, Alper, et al.
Izdano: (2024)

On the question of the stability of movement of steered wheels/
od: Soltus, A. P., et al.
Izdano: (1978)

Investigation on the conformational conversion of human prion protein by molecular dynamics simulation
od: Yang, Hong
Izdano: (2017)

Studies of the Conformational Dynamics of Ligand and Nucleotide Bound P-Glycoprotein
od: Ma, J, et al.
Izdano: (2013)

Molecular dissection of ionotropic glutamate receptor delta-family interactions with trans-synaptic proteins
od: Clay, J, et al.
Izdano: (2013)

Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism
od: Brown, P, et al.
Izdano: (2015)

Glutamate Receptors in Alzheimer’s Disease: Mechanisms and Therapies
od: Anggono, Victor, et al.
Izdano: (2016)

Contributions of metabotropic glutamate receptors to the pathophysiology of autism
od: Auerbach, Benjamin D. (Benjamin David)
Izdano: (2013)

Interdomain dynamics and ligand binding: molecular dynamics simulations of glutamine binding protein.
od: Pang, A, et al.
Izdano: (2003)

Molecular dynamics simulation approaches to K channels: conformational flexibility and physiological function.
od: Grottesi, A, et al.
Izdano: (2005)

An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing
od: Sánchez-Alcañiz, JA, et al.
Izdano: (2018)

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 1. Conformationally constrained glutamate
od: Bailey, J, et al.
Izdano: (2000)