Human prolyl hydroxylase domain 2 reacts with O 2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes

Hypoxia inducible transcription factors (HIFs) mediate the hypoxic response in metazoans. When sufficient O2 is present, Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases (human PHD1-3) promote HIFα degradation via prolyl-hydroxylation. We report crystallographic, spectroscopic, and biochemical chara...

詳細記述

書誌詳細
主要な著者: Fiorini, G, Marshall, SA, Figg, WD, Myers, WK, Brewitz, L, Schofield, CJ
フォーマット: Journal article
言語:English
出版事項: Nature Research 2024