Human prolyl hydroxylase domain 2 reacts with O 2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes

Hypoxia inducible transcription factors (HIFs) mediate the hypoxic response in metazoans. When sufficient O2 is present, Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases (human PHD1-3) promote HIFα degradation via prolyl-hydroxylation. We report crystallographic, spectroscopic, and biochemical chara...

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Bibliografische gegevens
Hoofdauteurs: Fiorini, G, Marshall, SA, Figg, WD, Myers, WK, Brewitz, L, Schofield, CJ
Formaat: Journal article
Taal:English
Gepubliceerd in: Nature Research 2024