Reduction of electron-deficient pyrroles using group I and II metals in ammonia

The preparation and Birch reduction of a series of electron-deficient pyrroles is described. This methodology allows the synthesis of a variety of C-2 substituted 3-pyrrolines in good to excellent yields. The role of various activating groups (amide, ester, carbamate and urea) has been examined with...

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Hlavní autoři: Donohoe, T, Guyo, P, Beddoes, R, Helliwell, M
Médium: Journal article
Jazyk:English
Vydáno: 1998