Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. Here, we employ single-cell assays for transposase-accessible chromatin (ATAC) and RNA sequencing in models of early treatment response and resistance to enzalu...

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Main Authors:	Taavitsainen, S, Engedal, N, Cao, S, Handle, F, Erickson, A, Prekovic, S, Wetterskog, D, Tolonen, T, Vuorinen, EM, Kiviaho, A, Nätkin, R, Häkkinen, T, Devlies, W, Henttinen, S, Kaarijärvi, R, Lahnalampi, M, Kaljunen, H, Nowakowska, K, Syvälä, H, Bläuer, M, Cremaschi, P, Claessens, F, Visakorpi, T, Tammela, TLJ, Murtola, T, Granberg, KJ, Lamb, AD, Ketola, K, Mills, IG, Attard, G, Wang, W, Nykter, M, Urbanucci, A
Format:	Journal article
Language:	English
Published:	Springer Nature 2021

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

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