Amantadine blocks channel activity of the transmembrane segment of the NB protein from influenza B.
NB is short auxiliary protein with ca. 100 amino acids, encoded in the viral genome of influenza B. It is believed to be similar to M2 from influenza A and Vpu from HIV-1 in that it demonstrates ion channel activity. Channels formed by the protein can be blocked by amantadine. We have synthesized th...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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