Ligand induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg 1433 and Tyr 1349
TRPM2 is a Ca2+-permeable non-selective cation channel activated by binding of adenosine 5ʹ-diphosphoribose (ADPR) to its cytoplasmic NUDT9H domain. Activation of TRPM2 by ADPR downstream of oxidative stress has been implicated in the pathogenesis of a number of human diseases rendering TRPM2 an att...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Portland Press
2017
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