NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice

Sensory nerves emanating from the dorsal root extensively innervate the surfaces of mammalian bone, a privileged location for the regulation of biomechanical signaling. Here, we show that NGF-TrkA signaling in skeletal sensory nerves is an early response to mechanical loading of bone and is required...

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Bibliographic Details
Main Authors: Tomlinson, R, Li, Z, Minichiello, L, Riddle, R, Venkatesan, A, Clemens, T
Format: Journal article
Language:English
Published: National Academy of Sciences 2017