Tolbutamide reverses membrane hyperpolarisation induced by activation of D2 receptors and GABAB receptors in isolated substantia nigra neurones.
A high density of binding sites for sulphonylureas is found in the substantia nigra. These binding sites may be linked to ATP-regulated K-channels (K-ATP channels) as sulphonylureas selectively inhibit these channels in pancreatic beta-cells. We have studied the effect of the sulphonylurea tolbutami...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1990
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