Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy.
Cardiac troponin I (cTnI) is the inhibitory component of the troponin complex and is involved in the calcium control of heart muscle contraction. Recently, specific missense mutations of the cTnI gene (TNNI3) have been shown to cause familial hypertrophic cardiomyopathy (HCM). We have analyzed the f...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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