Extrathymic signals regulate the onset of T cell repertoire selection.
The thymus is the principal site of T cell development, coordinating positive and negative selection of an immunocompetent repertoire. The ability of fetal thymi from C57BL/6 mice to support these selection events in culture is, however, critically dependent on the timing of their excision: whereas...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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