Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?
Accumulation of p53 protein was seen in the nuclei of mammalian cells following DNA damage caused by ultraviolet radiation (UV), X-ray, or a restriction enzyme. Promoters containing p53-binding sites show a dramatic transcriptional response to DNA damage. The p53 response to X-ray is rapid, reaching...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1993
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