Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.

Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.

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BACKGROUND: The endothelial nitric oxide synthase cofactor tetrahydrobiopterin (BH4) is essential for maintenance of enzymatic function. We hypothesized that induction of BH4 synthesis might be an endothelial defense mechanism against inflammation in vascular disease states. METHODS AND RESULTS: In...

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Bibliographic Details
Main Authors: Antoniades, C, Cunnington, C, Antonopoulos, A, Neville, M, Margaritis, M, Demosthenous, M, Bendall, J, Hale, A, Cerrato, R, Tousoulis, D, Bakogiannis, C, Marinou, K, Toutouza, M, Vlachopoulos, C, Leeson, P, Stefanadis, C, Karpe, F, Channon, K
Format: Journal article
Language:English
Published: 2011

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