T cell microvilli simulations show operation near packing limit and impact on antigen recognition

T cells are immune cells that continuously scan for foreign-derived antigens on the surfaces of nearly all cells, termed antigen-presenting cells (APCs). They do this by dynamically extending numerous protrusions called microvilli (MVs) that contain T cell receptors toward the APC surface in order t...

Full description

Bibliographic Details
Main Authors: Morgan, J, Pettmann, J, Dushek, O, Lindsay, AE
Format: Journal article
Language:English
Published: Cell Press 2022