T cell microvilli simulations show operation near packing limit and impact on antigen recognition
T cells are immune cells that continuously scan for foreign-derived antigens on the surfaces of nearly all cells, termed antigen-presenting cells (APCs). They do this by dynamically extending numerous protrusions called microvilli (MVs) that contain T cell receptors toward the APC surface in order t...
Main Authors: | Morgan, J, Pettmann, J, Dushek, O, Lindsay, AE |
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Format: | Journal article |
Language: | English |
Published: |
Cell Press
2022
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