Sharp injury to articular cartilage activates JNK and NF kappa B and induces expression of inflammatory response genes

Sharp injury to articular cartilage activates JNK and NF kappa B and induces expression of inflammatory response genes

Manylion Llyfryddiaeth
Prif Awduron:	Watt, F, Didangelos, A, Sawaji, Y, Saklatvala, J
Fformat:	Conference item
Cyhoeddwyd:	2006

Eitemau Tebyg

Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.
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Cyhoeddwyd: (2007)

Apolipoprotein A-1 is a novel inducer of aggrecan breakdown in cultured articular cartilage
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Cyhoeddwyd: (2009)

Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis.
gan: Saklatvala, J
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Activin is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B
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Cyhoeddwyd: (2008)

Src and fibroblast growth factor 2 independently regulate signaling and gene expression induced by experimental injury to intact articular cartilage.
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Cyhoeddwyd: (2012)

Activin A is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B
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Cyhoeddwyd: (2009)

Anti-catabolic effect of fibroblast growth factor-2 in human articular cartilage
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Cyhoeddwyd: (2009)

Dexamethasone inhibits aggrecanolysis in human articular cartilage but promotes it in porcine tissue
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Cyhoeddwyd: (2009)

Articular cartilage injury rapidly activates TAK1 in chondrocytes by inducing its phosphorylation and K63-polyubiquitination
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INTERLEUKIN 1 INDUCES AGGRECAN DEGRADATION BY HUMAN ARTICULAR CHONDROCYTES THROUGH A TAK1/MKK4/JNK2 PATHWAY WITHOUT INVOLVEMENT OF NFKB
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JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin
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Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage.
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The c-jun N-terminal kinase (JNK)-2 controls articular cartilage aggrecan degradation and progression of experimental osteoarthritis
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JNK2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis.
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Activation of mitogen activated Protein Kinases (MAPKs) and gene induction upon explantation in articular cartilage from wild type and FGF-2(-/-) mice
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Cyhoeddwyd: (2009)

Differential inflammatory gene expression patterns in JNK2 knockout mice in response to IL1, cartilage injury and surgically induced osteoarthritis
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BASIC FIBROBLAST GROWTH FACTOR (bFGF) MEDIATES THE IMMEDIATE INJURY RESPONSE IN ARTICULAR CARTILAGE
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Basic FGF mediates an immediate response of articular cartilage to mechanical injury.
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Pericellular matrix of articular cartilage. A novel mechanotransduction mechanism in articular chondrocytes?
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JNK-dependent modulation of the protease secretome profile of osteoarthritic cartilage
gan: Ismail, H, et al.
Cyhoeddwyd: (2018)

Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.
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Cyhoeddwyd: (2004)

Basic fibroblast growth factor: An extracellular mechanotransducer in articular cartilage?
gan: Vincent, T, et al.
Cyhoeddwyd: (2006)

Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage?
gan: Vincent, T, et al.
Cyhoeddwyd: (2006)

NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
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Cyhoeddwyd: (2001)

Basic fibroblast growth factor (FGF) mediator of the immediate injury response in articular cartilage
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Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats
gan: Gao H, et al.
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NF-kappaB Signaling in Chronic Inflammatory Airway Disease
gan: Michael Schuliga
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Two-dimensional electrophoresis of proteins secreted from articular cartilage.
gan: Hermansson, M, et al.
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Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
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Amygdalin Delays Cartilage Endplate Degeneration and Improves Intervertebral Disc Degeneration by Inhibiting NF-κB Signaling Pathway and Inflammatory Response
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Cyhoeddwyd: (2023-08-01)

Structural and regulatory components of the pericellular matrix of young and mature articular cartilage
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Induction of interleukin-1 in articular cartilage by explantation and cutting.
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NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.
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Effect of Knee Arthritis Therapeutic Apparatus on Structure and NF-κB Inflammatory Pathway in Articular Cartilage of Rabbits with Knee Osteoarthritis
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Caffeoylquinic Acid Derivatives Extract of Erigeron multiradiatus Alleviated Acute Myocardial Ischemia Reperfusion Injury in Rats through Inhibiting NF-KappaB and JNK Activations
gan: Zhifeng Zhang, et al.
Cyhoeddwyd: (2016-01-01)

Amygdalin Delays Cartilage Endplate Degeneration and Improves Intervertebral Disc Degeneration by Inhibiting NF-κB Signaling Pathway and Inflammatory Response [Corrigendum]
gan: Zeng Q, et al.
Cyhoeddwyd: (2024-04-01)

Aloe Extracts Inhibit Skin Inflammatory Responses by Regulating NF-κB, ERK, and JNK Signaling Pathways in an LPS-Induced RAW264.7 Macrophages Model
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Cyhoeddwyd: (2023-01-01)

Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases
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Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes.
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Connective tissue growth factor: matrix localisation, regulation and possible function in articular cartilage
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