Cardiovascular concentration-effect relationships of amodiaquine and its metabolite desethylamodiaquine: clinical and pre-clinical studies

<p><strong>Aims:&nbsp;</strong>Amodiaquine is a 4-aminoquinoline used extensively for the treatment and prevention of malaria. Orally administered amodiaquine is largely converted to the active metabolite desethylamodiaquine. Amodiaquine can cause bradycardia, hypotension, and...

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Main Authors: Chotsiri, P, Chan, XHS, Capel, RA, Pike, J, Hanboonkunupakarn, B, Lee, SJ, Hanafiah, M, Win, YN, Cremer, MA, Kiechel, J, Ogutu, B, Taylor, WRJ, Burton, RB, Tarning, J, White, NJ
Format: Journal article
Language:English
Published: Wiley 2022