CD73 and adenosine generation in the creation of regulatory microenvironments.
Extracellular adenosine 5'-triphosphate (ATP) acts on many immune cells to promote inflammation. Conversely, the ATP metabolite adenosine is mainly an anti-inflammatory molecule. The ecto-enzymes CD39 and CD73 can dephosphorylate extracellular ATP to adenosine, thereby controlling this importan...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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