Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions.

The cytoskeletal protein talin binds to a short C-terminal sequence in phosphatidylinositol phosphate kinase type Igamma (PIPKIgamma), activating the enzyme and promoting the local production of phosphatidylinositol 4,5 bisphosphate, which regulates focal adhesion dynamics as well as clathrin-mediat...

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Bibliographic Details
Main Authors: de Pereda, J, Wegener, K, Santelli, E, Bate, N, Ginsberg, M, Critchley, DR, Campbell, I, Liddington, R
Format: Journal article
Language:English
Published: 2005