Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions.

Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions.

The cytoskeletal protein talin binds to a short C-terminal sequence in phosphatidylinositol phosphate kinase type Igamma (PIPKIgamma), activating the enzyme and promoting the local production of phosphatidylinositol 4,5 bisphosphate, which regulates focal adhesion dynamics as well as clathrin-mediat...

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Detalles Bibliográficos
Autores principales: de Pereda, J, Wegener, K, Santelli, E, Bate, N, Ginsberg, M, Critchley, DR, Campbell, I, Liddington, R
Formato: Journal article
Lenguaje:English
Publicado: 2005

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