Re-evaluating the basis of clonal selection in germinal centres
Effective humoral responses rely on the development of high-affinity antigen-specific B cells. However, the naïve repertoire of antibodies usually shows low affinity. B cells need to improve their affinity in secondary lymphoid structures known as germinal centres (GCs) during infections, a process...
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| Format: | Thesis |
| Language: | English |
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2022
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