Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

There is a growing recognition of the importance of protein kinases in the control of alternative splicing. To define the underlying regulatory mechanisms, highly selective inhibitors are needed. Here, we report the discovery and characterization of the dichloroindolyl enaminonitrile KH-CB19, a pote...

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Bibliographic Details
Main Authors:	Fedorov, O, Huber, K, Eisenreich, A, Filippakopoulos, P, King, O, Bullock, A, Szklarczyk, D, Jensen, L, Fabbro, D, Trappe, J, Rauch, U, Bracher, F, Knapp, S
Format:	Journal article
Language:	English
Published:	2011
Subjects:	Alternative Splicing Phosphorylation chemistry Protein-Tyrosine Kinases Protein-Serine-Threonine Kinases drug effects chemical synthesis Models, Molecular Nitriles pharmacology antagonists and inhibitors Protein Kinase Inhibitors Thromboplastin metabolism RNA-Binding Proteins Catalytic Domain Substrate Specificity Endothelial Cells Heterocyclic Compounds, 2-Ring RNA, Messenger

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

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