Development of pyridine-based inhibitors for the human vaccinia-related kinases 1 and 2

Vaccinia-related kinases 1 and 2 (VRK1 and VRK2) are human Ser/Thr protein kinases associated with increased cell division and neurological disorders. Nevertheless, the cellular functions of these proteins are not fully understood. Despite their therapeutic potential, there are no potent and specifi...

Full description

Bibliographic Details
Main Authors: Serafim, R, De Souza Gama, F, Dutra, L, Dos Reis, C, Vasconcelos, S, Da Silva Santiago, A, Takarada, J, Di Pillo, F, Azevedo, H, Mascarello, A, Elkins, J, Massirer, K, Gileadi, O, Guimarães, C, Couñago, R
Format: Journal article
Language:English
Published: American Chemical Society 2019