Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis
The group A p21-activated kinases (PAKs) exist in an auto-inhibited form until activated by GTPase binding and auto-phosphorylation. In the auto-inhibited form, a regulatory domain binds to the kinase domain (KD) blocking the binding of substrates, and CDC42 or Rac binding to the regulatory domain r...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Portland Press
2019
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